Palazzo Artemide is a luxurious boutique hotel nestled in the historic heart of Ortigia, Syracuse, Sicily, within a beautifully restored 19th-century palazzo overlooking Piazza Minerva and near the ancient Temple of Athena. It blends original Baroque architecture, vaulted limestone ceilings, and neoclassical furnishings with contemporary Italian design. (Renovated: 2024; Rooms: 40)